Engineering Cells Through Programmable Mechanical Forces

ForCell is developing a proprietary microfluidic platform that uses programmable mechanical compression to engineer, condition, and deliver molecules into clinically-relevant human cells.

For decades, cell manufacturing and gene editing have focused almost entirely on biochemical control. Yet, cells naturally exist in environments where physical forces continually influence their behaviour, function, and genome engineering capacity. By applying controlled mechanical force, ForCell introduces a more efficient, non-viral approach to gene editing, stem-cell processing, and cell therapy manufacturing.

Why ForCell?

In the bone marrow, blood stem cells experience constant mechanical forces from surrounding tissue and the skeleton. The moment these cells are removed for processing, expansion, or gene editing, many of those physical cues disappear.

ForCell introduces controlled mechanical inputs back into the workflow using programmable microfluidic compression. By giving researchers precise regulation over force magnitude, pressure, and exposure duration, our platform provides a controlled way to apply mechanical stimulation during cell processing, gene editing, and cell therapy manufacturing.

Platform Capabilities

Cell Engineering & Gene Editing

Workflows for mechanically assisted cell engineering and genome-editing applications.

Non-Viral Intracellular Delivery

Mechanical approaches to introducing molecules into clinically relevant cells.

Adaptive Membrane Response

Study and control cellular membrane mechanics and response.

Stem-Cell Processing

Mechanical conditioning for stem-cell processing and expansion workflows.

Cell & Nuclear Mechanics

Investigate cell mechanics, nuclear architecture and mechanobiology.

Funding & Strategic Support

Translational & Proof-of-Concept

EPSRC PBIAA / Yorkshire MedTech logo
Cancer Research Horizons logo
Rosetrees Trust & Blood Cancer UK logo
European Research Council logo

Venture Building & Acceleration

Royal Academy of Engineering logo
Creative Destruction Lab logo
Blueprint by The Engine logo
BBSRC ICURe & Northern Accelerator logo

Meet Our Dedicated Agents

Dr Rasha Rezk

Founder

Mechanical engineer and inventor of the ForCell platform. Focuses on force-driven microfluidics for cell engineering, intracellular delivery, and mechanobiology.

Professor David Kent

Academic Co-Founder

Professor of Stem Cell Biology with expertise in haematopoietic stem cells, clonal haematopoiesis, and regenerative medicine.

Ella Mansfield

Research Scientist

Stem-cell biologist driving HSPC model development, assay design, and translational cell-engineering workflows.

Dr Lingyu Kong

Research Engineer

Biomedical engineer specialising in microfluidics, electronic control systems, and microfabrication.

Ellis Nicholson

Engineering Associate

Supports hardware development, prototyping, and demonstrator builds.

Global Network & Collaborations

Working with leading clinical and research institutions to benchmark and validate ForCell technology across primary cell workflows.

University College London logo
Boston Children's Hospital logo
University Health Network, Toronto logo
leeds teaching hospitals nhs trust logo

Advancing the next generation of cell engineering

We work with academic, clinical and industry partners exploring cell engineering, gene editing and cell therapy manufacturing.

Contact the Team

 

Interested in evaluating the platform or exploring a partnership?

Get in touch to discuss collaboration opportunities and technology evaluation